Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
Top Medical Research Studies
9
Cod liver oil aids rheumatoid arthritis
In a recent study involving 43 patients suffering from rheumatoid arthritis, we explored the impact of taking 1 gram of cod liver oil daily for three months. The results were striking. We observed notable reductions in morning stiffness by an impressive 52.4%, alongside decreases in both painful and swollen joints, each showing a 40% improvement. Pain intensity also saw a significant drop of 67.5%.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Read More
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
DHA shows promise for autoimmunity
We conducted a study to evaluate how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact autoimmune disorders, specifically using an animal model of multiple sclerosis (MS). In this investigation, we worked with twenty-five Dark Agouti rats, dividing them into distinct groups. Some received DHA, while others served as controls, allowing for comparisons of its effectiveness on clinical symptoms and levels of oxidative stress.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Read More
Most Useful Reviews
10
Improved health
9 people found this helpful
Excellent. My wife, diagnosed with liver cancer, has experienced significant improvements since we began using products from iherb.com, recommended by our doctor Antti Heikkilä. She feels stronger, can walk a bit, and has regained hope for more years. Initially, an oncologist gave her two months to live in November 2010 due to her severe condition. Thanks to Dr Heikkilä’s advice, she now believes there might be a chance for more time. Thank you, iherb.com and Antti Heikkilä, for your assistance!
Read More
0
Heartburn issue
1 people found this helpful
I experienced heartburn from these capsules, which I tried several times, but it happens consistently. My husband, however, has no issues with them. I have decided to order different supplements for myself.
Read More
7.5
Cognitive support
1 people found this helpful
This is not the first time I have ordered these capsules. I take them myself (at 64 years old), and my husband (67) takes them too. I recommend them to friends as I believe in their ideal combination of substances and convenient dosage of one capsule per day. I find they support brain activity and lift my spirits. I believe such drugs are essential to take consistently at my age, especially for maintaining good cognitive health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.7
- All Researches
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
Cod liver oil aids rheumatoid arthritis
In a recent study involving 43 patients suffering from rheumatoid arthritis, we explored the impact of taking 1 gram of cod liver oil daily for three months. The results were striking. We observed notable reductions in morning stiffness by an impressive 52.4%, alongside decreases in both painful and swollen joints, each showing a 40% improvement. Pain intensity also saw a significant drop of 67.5%.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Read More
9
DHA mediators reduce RA symptoms
We explored how lipid mediators derived from docosahexaenoic acid (DHA) impact rheumatoid arthritis (RA), an autoimmune disorder marked by inflammation and joint damage. In our investigation, we noted that a specific combination of lipid mediators produced from DHA, including 17S-monohydroxy docosahexaenoic acid, resolvin D5, and protectin DX, showed promise in reducing arthritis severity.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
Read More
9
DHA shows promise for autoimmunity
We conducted a study to evaluate how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact autoimmune disorders, specifically using an animal model of multiple sclerosis (MS). In this investigation, we worked with twenty-five Dark Agouti rats, dividing them into distinct groups. Some received DHA, while others served as controls, allowing for comparisons of its effectiveness on clinical symptoms and levels of oxidative stress.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Read More
9
We investigated how docosahexaenoic acid (DHA), a key fatty acid, influences autoimmune disorders like multiple sclerosis (MS). Our findings revealed that fatty acid metabolism, particularly through the enzyme stearoyl-CoA desaturase-1 (SCD1), plays a critical role in the differentiation of regulatory T cells (Tregs), which are important for maintaining immune balance.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
10
Improved health
9 people found this helpful
Excellent. My wife, diagnosed with liver cancer, has experienced significant improvements since we began using products from iherb.com, recommended by our doctor Antti Heikkilä. She feels stronger, can walk a bit, and has regained hope for more years. Initially, an oncologist gave her two months to live in November 2010 due to her severe condition. Thanks to Dr Heikkilä’s advice, she now believes there might be a chance for more time. Thank you, iherb.com and Antti Heikkilä, for your assistance!
Read More
0
Heartburn issue
1 people found this helpful
I experienced heartburn from these capsules, which I tried several times, but it happens consistently. My husband, however, has no issues with them. I have decided to order different supplements for myself.
Read More
7.5
Cognitive support
1 people found this helpful
This is not the first time I have ordered these capsules. I take them myself (at 64 years old), and my husband (67) takes them too. I recommend them to friends as I believe in their ideal combination of substances and convenient dosage of one capsule per day. I find they support brain activity and lift my spirits. I believe such drugs are essential to take consistently at my age, especially for maintaining good cognitive health.
Read More
Frequently Asked Questions
10
Improved health
9 people found this helpful
Excellent. My wife, diagnosed with liver cancer, has experienced significant improvements since we began using products from iherb.com, recommended by our doctor Antti Heikkilä. She feels stronger, can walk a bit, and has regained hope for more years. Initially, an oncologist gave her two months to live in November 2010 due to her severe condition. Thanks to Dr Heikkilä’s advice, she now believes there might be a chance for more time. Thank you, iherb.com and Antti Heikkilä, for your assistance!
7.5
Cognitive support
1 people found this helpful
This is not the first time I have ordered these capsules. I take them myself (at 64 years old), and my husband (67) takes them too. I recommend them to friends as I believe in their ideal combination of substances and convenient dosage of one capsule per day. I find they support brain activity and lift my spirits. I believe such drugs are essential to take consistently at my age, especially for maintaining good cognitive health.
0
Heartburn issue
1 people found this helpful
I experienced heartburn from these capsules, which I tried several times, but it happens consistently. My husband, however, has no issues with them. I have decided to order different supplements for myself.
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
8
We explored the connection between vitamin D levels and the management of Graves' disease, an autoimmune disorder characterized by overactive thyroid function. Through our research with 171 patients, we aimed to see if pre-treatment levels of 25-hydroxyvitamin D could influence the reduction of thyrotropin receptor antibodies (TRAB) during treatment.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
8
Calcitriol enhances MSCs in RA
We investigated the effects of calcitriol, an active form of vitamin D, on mesenchymal stem cells (MSCs) in the context of rheumatoid arthritis (RA), a chronic inflammatory disease affecting joints. Using BALB/c mice, we induced RA with collagen and Freund's complete adjuvant and divided the mice into three groups: untreated, treated with untreated MSCs, and treated with calcitriol-exposed MSCs.
Our findings revealed that MSCs treated with calcitriol showcased enhanced regulatory functions, particularly regarding immune responses from splenocytes. This treatment also resulted in reduced inflammatory markers. Importantly, we observed how calcitriol modulated the production of certain cytokines, increasing levels of IL-4, IL-10, and TGF-β, while decreasing INF-γ and IL-17 compared to the positive control group.
Overall, this study highlights the potential of calcitriol treated MSCs in improving immune regulation, offering promising insights for future advanced therapies in autoimmune disorders like RA.
Our findings revealed that MSCs treated with calcitriol showcased enhanced regulatory functions, particularly regarding immune responses from splenocytes. This treatment also resulted in reduced inflammatory markers. Importantly, we observed how calcitriol modulated the production of certain cytokines, increasing levels of IL-4, IL-10, and TGF-β, while decreasing INF-γ and IL-17 compared to the positive control group.
Overall, this study highlights the potential of calcitriol treated MSCs in improving immune regulation, offering promising insights for future advanced therapies in autoimmune disorders like RA.
7
We explored how vitamin D interacts with other factors like Epstein-Barr virus (EBV) infection to influence autoimmune disorders, particularly multiple sclerosis (MS). Research shows that individuals who are deficient in vitamin D are at a greater risk of developing MS. This suggests that vitamin D could play a protective role, potentially helping to modulate the immune response in these patients.
In our observations, adequate levels of vitamin D appear to support a balanced immune system. This balance is crucial because an overactive immune response can lead to the body attacking its own tissues, as seen in MS. Additionally, studies suggest that vitamin D may enhance the effectiveness of our immune cells, which could provide some level of defense against triggering factors like EBV.
However, while the connection between low vitamin D levels and an increased risk of MS is well-recognized, there is still ongoing debate regarding the direct benefits of vitamin D supplementation in treating MS. We recognize the need for further research to clarify its effectiveness and potential as a therapeutic option.
Overall, vitamin D's interaction with the immune system offers intriguing possibilities, which we believe may lead to new approaches for managing autoimmune disorders.
In our observations, adequate levels of vitamin D appear to support a balanced immune system. This balance is crucial because an overactive immune response can lead to the body attacking its own tissues, as seen in MS. Additionally, studies suggest that vitamin D may enhance the effectiveness of our immune cells, which could provide some level of defense against triggering factors like EBV.
However, while the connection between low vitamin D levels and an increased risk of MS is well-recognized, there is still ongoing debate regarding the direct benefits of vitamin D supplementation in treating MS. We recognize the need for further research to clarify its effectiveness and potential as a therapeutic option.
Overall, vitamin D's interaction with the immune system offers intriguing possibilities, which we believe may lead to new approaches for managing autoimmune disorders.
4
We set out to discover how effective vitamin D is in treating autoimmune disorders, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved looking at several studies examining various dietary supplements, including selenium and vitamin D, to see how they impact thyroid autoantibody levels and overall thyroid function.
Within the studies we reviewed, vitamin D did not seem to significantly reduce thyroid autoantibody levels like other supplements. In particular, we noted that treatments involving vitamin D, whether alone or in combination with other nutrients, did not show a meaningful effect on reducing thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of significant benefit suggests that while vitamin D is often included in treatment plans for autoimmune disorders, it may not play a critical role in alleviating the symptoms or autoimmunity associated with HT. Therefore, it might be wise for those seeking supplemental help to consider other options, particularly selenium, which showed more promising results.
Within the studies we reviewed, vitamin D did not seem to significantly reduce thyroid autoantibody levels like other supplements. In particular, we noted that treatments involving vitamin D, whether alone or in combination with other nutrients, did not show a meaningful effect on reducing thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of significant benefit suggests that while vitamin D is often included in treatment plans for autoimmune disorders, it may not play a critical role in alleviating the symptoms or autoimmunity associated with HT. Therefore, it might be wise for those seeking supplemental help to consider other options, particularly selenium, which showed more promising results.
7
We examined the potential impact of vitamin D on autoimmune disorders, specifically focusing on its effects in patients with Antiphospholipid Syndrome (APS). APS is a complex autoimmune condition that leads to issues like blood clots and complications during pregnancy, largely tied to immune system disturbances. Given the uncertain prognosis of APS, current treatment primarily revolves around anticoagulation therapy to prevent blood clots.
Recent research has shed light on how vitamin D might play a beneficial role in regulating immune cells, thus offering hope for those affected by APS. By potentially restoring the balance of immune responses, vitamin D could serve as a valuable complementary treatment alongside conventional therapies. This finding underscores the importance of further exploring vitamin D's mechanisms and its broader applications in autoimmune disorders.
Overall, while vitamin D appears promising as an adjunct therapy for APS, research is still developing. We look forward to seeing how this vitamin could improve immune regulation for patients dealing with challenges related to autoimmune diseases.
Recent research has shed light on how vitamin D might play a beneficial role in regulating immune cells, thus offering hope for those affected by APS. By potentially restoring the balance of immune responses, vitamin D could serve as a valuable complementary treatment alongside conventional therapies. This finding underscores the importance of further exploring vitamin D's mechanisms and its broader applications in autoimmune disorders.
Overall, while vitamin D appears promising as an adjunct therapy for APS, research is still developing. We look forward to seeing how this vitamin could improve immune regulation for patients dealing with challenges related to autoimmune diseases.
References
- Vernerová L, Vokurková M, Laiferová NA, Nemec M, Špiritović M, et al. Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis. Arthritis Res Ther. 2025;27:48. doi:10.1186/s13075-025-03516-9
- Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, et al. Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. Front Immunol. 2025;16:1528707. doi:10.3389/fimmu.2025.1528707
- Chen X, Zhang Y, Lin L, Chen Y, Shen X, et al. A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves' disease: a real-world study. BMC Endocr Disord. 2025;25:14. doi:10.1186/s12902-024-01823-x
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. doi:10.1016/j.transproceed.2024.12.020
- Casas R, Tompa A, Åkesson K, Teixeira PF, Lindqvist A, et al. Redosing with Intralymphatic GAD-Alum in the Treatment of Type 1 Diabetes: The DIAGNODE-B Pilot Trial. Int J Mol Sci. 2025;26. doi:10.3390/ijms26010374
- Rasheed A, Khan G. Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Front Immunol. 2024;15:1503808. doi:10.3389/fimmu.2024.1503808
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. doi:10.1111/jocd.16740
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Balshi A, Leuenberger G, Dempsey J, Baber U, Sloane JA. Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort. Mult Scler Relat Disord. 2025;93:106229. doi:10.1016/j.msard.2024.106229
- Mourelatou NG, Kounatidis D, Jude EB, Rebelos E. Vitamin D Supplementation as a Therapeutic Strategy in Autoimmune Diabetes: Insights and Implications for LADA Management. Nutrients. 2024;16. doi:10.3390/nu16234072
- Huo R, Yang Y, Wei C, Huo X, Meng D, et al. Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). Int J Mol Med. 2025;55. doi:10.3892/ijmm.2024.5471
- Kilani Y, Alsakarneh S, Madi MY, Mosquera DAG, Ferreira MN, et al. Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective. Aliment Pharmacol Ther. 2025;61:682. doi:10.1111/apt.18438
- Cortese M, Riise T, Bjørnevik K, Holmøy T, Kampman MT, et al. Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study. Mult Scler. 2015;21:1856. doi:10.1177/1352458515578770
- McDowell TY, Amr S, Culpepper WJ, Langenberg P, Royal W, et al. Sun exposure, vitamin D intake and progression to disability among veterans with progressive multiple sclerosis. Neuroepidemiology. 2011;37:52. doi:10.1159/000329258
- McDowell TY, Amr S, Culpepper WJ, Langenberg P, Royal W, et al. Sun exposure, vitamin D and age at disease onset in relapsing multiple sclerosis. Neuroepidemiology. 2011;36:39. doi:10.1159/000322512
- Galarraga B, Ho M, Youssef HM, Hill A, McMahon H, et al. Cod liver oil (n-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis. Rheumatology (Oxford). 2008;47:665. doi:10.1093/rheumatology/ken024
- Norris JM, Yin X, Lamb MM, Barriga K, Seifert J, et al. Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes. JAMA. 2007;298:1420.
- Kampman MT, Wilsgaard T, Mellgren SI. Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle. J Neurol. 2007;254:471.
- Vermel' AE. [Clinical application of omega-3-fatty acids (cod-liver oil)]. Klin Med (Mosk). 2005;83:51.
- Gruenwald J, Graubaum HJ, Harde A. Effect of cod liver oil on symptoms of rheumatoid arthritis. Adv Ther. 2002;19:101.
- Blaser J, Triebel S, Maasjosthusmann U, Romisch J, Krahl-Mateblowski U, et al. Determination of metalloproteinases, plasminogen-activators and their inhibitors in the synovial fluids of patients with rheumatoid arthritis during chemical synoviorthesis. Clin Chim Acta. 1996;244:17.
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