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SCIENTIFIC SCORE
Possibly Effective
Based on 54 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
Top Medical Research Studies
9
Cod liver oil aids rheumatoid arthritis
Effect of cod liver oil on symptoms of rheumatoid arthritis.
Highly relevant for treatment insights
In a recent study involving 43 patients suffering from rheumatoid arthritis, we explored the impact of taking 1 gram of cod liver oil daily for three months. The results were striking. We observed notable reductions in morning stiffness by an impressive 52.4%, alongside decreases in both painful and swollen joints, each showing a 40% improvement. Pain intensity also saw a significant drop of 67.5%.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Read More
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Directly addresses eicosapentaenoic acid
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
Read More
9.5
Vitamin D3 aids autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Highly relevant to autoimmune research
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
Most Useful Reviews
10
Improved health
Excellent. My wife, diagnosed with liver cancer, has experienced significant improvements since we began using products from iherb.com, recommended by our doctor Antti Heikkilä. She feels stronger, can walk a bit, and has regained hope for more years. Initially, an oncologist gave her two months to live in November 2010 due to her severe condition. Thanks to Dr Heikkilä’s advice, she now believes there might be a chance for more time. Thank you, iherb.com and Antti Heikkilä, for your assistance!
Read More
2.5
Heartburn issue
I experienced heartburn from these capsules, which I tried several times, but it happens consistently. My husband, however, has no issues with them. I have decided to order different supplements for myself.
Read More
8.8
Cognitive support
This is not the first time I have ordered these capsules. I take them myself (at 64 years old), and my husband (67) takes them too. I recommend them to friends as I believe in their ideal combination of substances and convenient dosage of one capsule per day. I find they support brain activity and lift my spirits. I believe such drugs are essential to take consistently at my age, especially for maintaining good cognitive health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 54 Researches
7.6
9.5
Vitamin D3 aids autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Highly relevant to autoimmune research
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
Cod liver oil aids rheumatoid arthritis
Effect of cod liver oil on symptoms of rheumatoid arthritis.
Highly relevant for treatment insights
In a recent study involving 43 patients suffering from rheumatoid arthritis, we explored the impact of taking 1 gram of cod liver oil daily for three months. The results were striking. We observed notable reductions in morning stiffness by an impressive 52.4%, alongside decreases in both painful and swollen joints, each showing a 40% improvement. Pain intensity also saw a significant drop of 67.5%.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Additionally, the feedback from the patients was overwhelmingly positive. Approximately 68% reported that the treatment was effective, while a remarkable 95% praised its tolerability. However, it’s worth noting that 11 patients did experience some nonsevere adverse effects, but only three of those were possibly related to the cod liver oil itself.
Overall, it seems that cod liver oil can indeed offer relief for those grappling with rheumatoid arthritis, making it a treatment worth considering for improving symptoms of this autoimmune disorder.
Read More
9
DHA mediators reduce RA symptoms
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis.
Mixed effects observed in study
We explored how lipid mediators derived from docosahexaenoic acid (DHA) impact rheumatoid arthritis (RA), an autoimmune disorder marked by inflammation and joint damage. In our investigation, we noted that a specific combination of lipid mediators produced from DHA, including 17S-monohydroxy docosahexaenoic acid, resolvin D5, and protectin DX, showed promise in reducing arthritis severity.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
Read More
9
DHA shows promise for autoimmunity
Neuroprotective and antioxidant effects of docosahexaenoic acid (DHA) in an experimental model of multiple sclerosis.
Direct impact on autoimmune disorder
We conducted a study to evaluate how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact autoimmune disorders, specifically using an animal model of multiple sclerosis (MS). In this investigation, we worked with twenty-five Dark Agouti rats, dividing them into distinct groups. Some received DHA, while others served as controls, allowing for comparisons of its effectiveness on clinical symptoms and levels of oxidative stress.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Read More
9
DHA's Role in Treg Differentiation
Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity.
High relevance to Treg differentiation
We investigated how docosahexaenoic acid (DHA), a key fatty acid, influences autoimmune disorders like multiple sclerosis (MS). Our findings revealed that fatty acid metabolism, particularly through the enzyme stearoyl-CoA desaturase-1 (SCD1), plays a critical role in the differentiation of regulatory T cells (Tregs), which are important for maintaining immune balance.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
10
Improved health
Excellent. My wife, diagnosed with liver cancer, has experienced significant improvements since we began using products from iherb.com, recommended by our doctor Antti Heikkilä. She feels stronger, can walk a bit, and has regained hope for more years. Initially, an oncologist gave her two months to live in November 2010 due to her severe condition. Thanks to Dr Heikkilä’s advice, she now believes there might be a chance for more time. Thank you, iherb.com and Antti Heikkilä, for your assistance!
Read More
8.8
Cognitive support
This is not the first time I have ordered these capsules. I take them myself (at 64 years old), and my husband (67) takes them too. I recommend them to friends as I believe in their ideal combination of substances and convenient dosage of one capsule per day. I find they support brain activity and lift my spirits. I believe such drugs are essential to take consistently at my age, especially for maintaining good cognitive health.
Read More
2.5
Heartburn issue
I experienced heartburn from these capsules, which I tried several times, but it happens consistently. My husband, however, has no issues with them. I have decided to order different supplements for myself.
